Genzifen Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Tamoxifen citrate

Indications/Uses

Breast cancer.

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Dosage/Direction for Use

Adult including elderly 20-40 mg daily in divided doses bid or as single dose once daily.

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Overdosage

View Genzifen overdosage for action to be taken in the event of an overdose.

Administration

May be taken with or without food.

Contraindications

Hypersensitivity. Pregnancy.

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Special Precautions

Suppressed menstruation. Increased incidence of endometrial cancer & uterine sarcoma. May affect development of endometrial pathology including neoplasia. 2nd primary tumours. May increase risk of microvascular flap complications in delayed microsurgical breast reconstruction. Avoid concomitant use w/ potent CYP2D6 inhibitors eg, paroxetine, fluoxetine, quinidine, cinacalcet or bupropion. Not to be taken by patients w/ galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. May affect ability to drive & use machines. Sexually-active women should use barrier or other non-hormonal contraception. Not recommended during lactation. Not recommended in childn.

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Use In Pregnancy & Lactation

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Adverse Reactions

Fluid retention; hot flushes; nausea; skin rash; vag bleeding & discharge; fatigue. Uterine fibroids; anaemia; hypersensitivity reactions; ischaemic cerebrovascular events, headache, light headedness, sensory disturbances (including paraesthesia & dysgeusia); cataracts, retinopathy; vomiting, diarrhea, constipation; changes in liver enzymes, fatty liver; alopecia; leg cramp, myalgia; pruritus valvae, endometrial changes (including hyperplasia & polyps); elevated triglycerides; thromboembolic events (including DVT, microvascular thrombosis & pulmonary embolism).

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Drug Interactions

Increased anticoagulant effect of coumarin-type anticoagulants. Increased risk of thromboembolic events w/ cytotoxic agents. Reduced plasma levels w/ CYP3A4 inducer eg, rifampicin. Reduced efficacy w/ SSRI antidepressants (eg, paroxetine) & potent CYP2D6 inhibitors (eg, paroxetine, fluoxetine, quinidine, cinacalcet or bupropion).

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Storage

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Description

View Genzifen description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Cancer Hormone Therapy

ATC Classification

L02BA01 - tamoxifen ; Belongs to the class of anti-estrogens. Used in treatment of neoplastic diseases.

Regulatory Classification

Presentation/Packing

Form

Genzifen FC tab 20 mg

Packing/Price

30's

Genzifen

tamoxifen

Manufacturer:

General

Distributor:

Genace Pharma

Marketer:

Ambica