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If any improvement of gastrointestinal symptoms is not observed after the administration for a given period of time (usually for 2 weeks), Mosapride Citrate (GASTIIN CR) should not be administered for a long period of time.
Administering this drug with food may raise the blood concentration of this drug, so it shall be administered in an empty stomach. When this drug was administered on a single dose after a high-fat diet, Cmax, AUC were increased by 78% and 39% respectively compared to when administered on an empty stomach.
Others: When 100-330 times of the recommended clinical dose (30-100 mg/kg/day) of mosapride citrate was orally administered in rodents for long period (104 weeks in rats, 92 weeks in mice), increased incidence of hepatocellular adenoma and thyroid follicular cell adenoma were observed.
Use in Children: Safety in children has not been established (no clinical experience).
Use in the Elderly: Since the physiological function in the kidneys and liver are generally reduced in the elderly patients, Mosapride Citrate (GASTIIN CR) should be administered with care by monitoring patients' condition. If any adverse reactions are found, appropriate measures e.g., reducing the dose (e.g. to 7.5 mg/day) should be given.
