Gastiin CR Mechanism of Action

Drug for Functional Gastrointestinal Disorders (Propulsive).
Pharmacology: Pharmacodynamics: Mechanism of Action: Mosapride Citrate is a selective 5-HT4 receptor agonist. It is considered that mosapride citrate stimulates 5-HT4 receptors in the gastrointestinal nerve plexus, which increases the release of acetylcholine (ACh), resulting in enhancement of gastrointestinal motility and gastric emptying.
Gastroprokinetic Effect: Mosapride Citrate increased gastric and duodenal motility after meals in conscious dogs.
Gastric Emptying Enhancing Effect: Mosapride Citrate enhances gastric emptying of liquid (in mice and rats) and solid (in rats) contents. The gastric emptying enhancing effect was decreased after 1-week repeated administration (in rats).
Pharmacokinetics: After oral administration of single dose of Mosapride 5-40 mg, peak Mosapride concentration (Cmax) was reached after ~1 hour. Mean elimination half-lives (t) were 1.4-2.0 hours.
Plasma Cmax (52.0 ng/mL) of the active M 1 metabolite occurred 0.5 hours after a single dose of mosapride 40 mg. Elimination of M 1 (t = 4.3 hours).
Mosapride is excreted in urine and feces in 48 hours after administration of a single dose of Mosapride 5 mg.