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Acute life-threatening toxicity has not been observed with gabapentin overdose of up to 49 g. Symptoms of the overdosage included dizziness, double vision, slurred speech, drowsiness, lethargy and mild diarrhea. Reduced absorption of gabapentin at higher doses may limit drug absorption at the time of overdosing and, hence, minimize toxicity overdose.
Overdose of gabapentin, particularly in combination with other CNS depressant medications may result in coma.
In patients with severe renal impairment, hemodialysis may be indicated.
