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Ifosfamide is given intravenously, either by injection as a solution diluted to less than 4%, or by infusion. Licensed dosage regimens include a total dose of 8 to 12 g/m2 divided over 3 to 5 days, with the course repeated at 2 to 4 week intervals; a total dose of 6 g/m2 divided over 5 days, repeated every 3 weeks; and doses of 5 to 6 g/m2, to a maximum of 10 g, given as a single 24-hour infusion, repeated at 3 to 4 week intervals. The interval between courses also depends on the blood count.
Ifosfamide should be given with mesna and adequate hydration should be maintained, to avoid urological toxicity; fluid intake should not be less than 2 litres daily.
Or as directed by the physician.
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