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Primary hypercholesterolaemia, combine hyperlipidaemia, 10-20 mg daily at night, adjusted at intervals of at least 4 weeks; usual range 10-80 mg once daily at night. Homozygous familial hypercholesterolaemia, 40 mg daily at night or 80 mg daily in 3 divided doses (with largest dose at night). Prevention of cardiovascular events, initially 20-40 mg daily at night, adjusted at intervals of at least 4 weeks; maximum 80 mg once daily at night.
Note: Maximum 10 mg daily with concomitant ciclosporin, fibrate or lipid-lowering dose of nicotinic acid. Maximum 20 mg daily with concomitant amiodarone or verapamil. Maximum 40 mg daily with diltiazem.
