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Should not be given alone or with inadequate vitamin B12 for the treatment of pernicious anemia or undiagnosed megaloblastic anemia and in patients with folate-dependent tumors.
Large and continuous dosage folic acid may lower the blood concentration of vitamin B12. Folic acid does not correct folate deficiency due to dihydrofolate reductase inhibitors.
The availability of folates may be inhibited by gastric acidity and the presence of ascorbate in the gastrointestinal tract. Metformin reduces intestinal absorption of folic acid and phenytoin may cause folate depletion.
Use in Pregnancy: See Use in Pregnancy & Lactation section for further information.
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