Paracetamol is given by mouth or as a rectal suppository for mild to moderate pain and for fever. Paracetamol is often the analgesic or antipyretic of choice especially in patients in whom salicylates or other NSAIDs are contraindicated. Such patients include asthmatics or those with a history of peptic ulcer, or children in whom salicylates are contraindicated because of the risk of Reye's syndrome.