Course of treatment: 7 days, may be continued for up to 14 days if required. Adult & childn >10 yr or >50 kg 200-400 mg daily as single dose or in 2 divided doses. Elderly Adult dose may be given. Patient w/ CrCl <20 mL/min & those maintained on chronic ambulatory peritoneal dialysis or hemodialysis Not to exceed 200 mg once daily.
Hypersensitivity to penicillins. Discontinue use at 1st appearance of skin rash, mucosal lesions, or any other sign of skin hypersensitivity; if acute renal failure occurs. Predisposition to encephalopathy risk (including convulsions, confusion, impairment of consciousness, movement disorders). Hemolytic anemia. Antibiotic-associated colitis. Renal impairment. Not to be used in pregnancy or lactation. Not recommended in childn <10 yr. Childn <6 mth; premature or newborn infant.
Increased prothrombin time w/ anticoagulants. May enhance effects of coumarin-type anticoagulants (eg, warfarin K) & prolong prothrombin time w/ or w/o bleeding. False +ve reaction for glucose in urine w/ Benedict's or Fehling's soln or w/ Cu sulphate test tab; direct Coombs test.
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