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Recommended Dose: For the treatment of hyperuricaemia in patients with gout, Febuxostat tablets are recommended at a dosage of 40 mg or 80 mg or 120 mg once daily.
The recommended starting dose is 40 mg once daily. For patient who do not achieve a serum uric acid (sUA) less than 6 mg per dL after 2 weeks with 40 mg, Febuxostat tablets 80 mg is recommended.
Febuxostat tablets can be taken without regard to food or antacid use.
Uric Acid Level: Testing for the target sUA level <6 mg/dL may be performed as early as 2 weeks after initiating Febuxostat tablets therapy.
Gout Flares: Gout flares may occur after initiation of Febuxostat tablets due to changing sUA levels, resulting in mobilization of urate from tissue deposits. Flare prophylaxis with a nonsteroidal anti-inflammatory drug (NSAID) or colchicine is recommended upon initiation of therapy with Febuxostat tablets. Prophylactic therapy may be beneficial for up to 6 months.
If a gout flare occurs during Febuxostat tablets treatment, they need not be discontinued. The gout flare should be managed concurrently, as appropriate for the individual patient.
Febuxostat tablets are not recommended for the treatment of asymptomatic hyperuricaemia.
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