Etopul Caution For Usage

Etoposide should not be used without diluting. Dilute with 0.9% sodium chloride or 5% dextrose. Solutions showing any signs of precipitation should not be used.
For waste-disposal and safety information guidelines on safe-handling of antineoplastic drugs should be followed. Any contact with the fluid should be avoided. During preparation and reconstitution a strictly aseptic working technique should be used; protective measures should include the use of gloves, mask, safety goggles and protective clothing. Use of a vertical laminar airflow (LAF) hood is recommended.
Gloves should be worn during administration. Waste-disposal procedures should take into account the cytotoxic nature of this substance.
If etoposide contacts skin, mucosae or eyes, immediately wash thoroughly with water. Soap may be used for skin cleansing.
Precaution in Administration: Etoposide should be diluted to the concentration of not more than 0.25 mg/mL to avoid precipitation. The reconstituted solution should be used immediately after reconstitution.