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Drugs which reduce gastric acidity may result in a lower bioavailability of Cefuroxime (as axetil) compared with that of the fasting state and tend to cancel the effect of enhanced post-prandial absorption.
In common with other antibiotics, Cefuroxime (as axetil) may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral contraceptives.
As a false-negative result may occur in the ferricyanide test, it is recommended that either the glucose oxidase or hexokinase methods a blood/plasma glucose levels in patients receiving Cefuroxime (as axetil).
This antibiotic does not interfere in the alkaline picrate assay for creatinine.
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