Ephron Mechanism of Action

Pharmacology: Pharmacodynamics: Mechanism of Action: Cefaclor is a bactericidal cephalosporin and like other cephalosporins is an inhibitor of bacterial cell wall synthesis. It acylates membrane-bound transpeptidase enzymes thus preventing the cross-linking of peptidoglycan necessary for bacterial cell wall strength and rigidity.
Pharmacokinetics: Cefaclor is well absorbed after oral administration. The presence of food may delay the absorption of cefaclor, but the total amount absorbed remains unchanged. Serum levels of 6 mg/1 mcg and 13 mg/1 mcg are obtained after 250 mg and 500 mg of cefaclor respectively. Peak serum concentrations are obtained in 0.5 hour to 1 hour. About 25% is protein bound. Cefaclor is widely distributed in the body. It is rapidly excreted by the kidneys, up to 85% of a dose appears unchanged in the urine within two hours. The plasma elimination half life cefaclor is about 30 minutes to 1 hour.