Drozid Special Precautions

In penicillin-allergic patients due to the possibility of cross-allergy. If a hypersensitivity reaction occurs, cefadroxil should be discontinued and the patient treated with usual agents (eg, epinephrine or other pressor amines, antihistamines or corticosteroids).
Should be used with caution in the presence of impaired renal function (CrCl <50 mL/min/1.73 m²) and patients with colitis.
Reproduction study in mice and rats with doses up to 11 times the human dose have revealed no evidence of impaired fertility or harm to the fetus due to cefadroxil, there are however, no adequate and well-controlled studies in pregnant women.
Prolonged use of cefadroxil may result in the overgrowth of nonsusceptible organisms.
Positive Benedict's, Fehling's or Clinitest tablet's test in glycosuria were reported during treatment with cefadroxil. But not if using enzymatic reaction like Clinistix.
Use in pregnancy & lactation: Although there have been no reports of adverse effects to the fetus to date, safe use of cephalosporins during pregnancy has not been definitely established.
Cefadroxil should be used during pregnancy only when clearly needed.
Cephalosporins are distributed into milk, so cefadroxil should be used with caution in nursing women.