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Concomitant administration of oral probenecid competitively inhibits tubular secretion resulting in higher and more prolonged serum concentration of most cephalosporins.
Concurrent use of nephrotoxic agents eg, aminoglycosides, colistin, polymyxin B or vancomycin may increase the risk of nephrotoxicity with some cephalosporins and probably should be avoided, if possible may be additive or synergistic with aminoglycoside or penicillins against some organisms.
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