No evidence of a relationship between doxofylline serum concentration and toxic events has been reported with potential drug interactions. Doxofylline reacts with broad variety of drugs that alter the rate of theophylline clearance leading to increase or decrease of serum theophylline concentration. Because of narrow therapeutic index, serum theophylline concentration need to be monitored. Conversely because of a wider therapeutic window there is no need to monitor doxofylline levels.
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