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Methyldopa should be used with caution in patients with impaired renal or hepatic function or history of hemolytic anemia, liver disease, or depression. It should not be given to patients with active liver disease or depression and it is not recommended for phaeochromocytoma.
Patients taking methyldopa may produce a positive response to a direct Coomb's test; if blood transfusion is required, prior knowledge of a positive direct Coomb's test reaction will aid cross-matching.
Methyldopa may cause sedation; affected patients is not advisable to drive or operate machinery.
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