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The hypotension effects of methyldopa are potentiated by diuretics, other antihypertensive, and drugs with hypertensive effects. However, there have been reports of paradoxical antagonism of the hypotensive effects by tricyclic antidepressants, antipsychotics, and beta blockers. Sympathomimetics may also antagonize the hypotensive effects.
There may be an interaction between methyldopa and MAOIs and care is required if they are given concomitantly. Caution is also needed with entacapone since it might inhibit the metabolism of methyldopa. Patient receiving methyldopa may require lower doses of general anesthetics.
