Dometab

Prevention & symptomatic relief of acute nausea & vomiting in adults from cytotoxic therapy, RT; nausea & vomiting associated w/ L-dopa & bromocriptine treatment for parkinsonian patients; nausea associated w/ migraine attacks. Stimulation of gut mobility including non-ulcer dyspepsia, esophageal reflux, reflux esophagitis, gastritis, speeding barium transit in follow-through radiological studies, diabetic gastroparesis. Functional dyspepsia.

Adult & adolescent ≥12 yr & ≥35 kg 10 mg tab up to tid, max 30 mg/day. Treatment duration should not exceed 1 wk.

Should be taken on an empty stomach: Take 15-30 min before meals.

Hypersensitivity. Not to be used when GI stimulation might be dangerous ie, GI haemorrhage, obstruction, perforation or immediately after surgery. Neonates.

QT prolongation & increased risk of serious ventricular arrhythmias or sudden cardiac death. Prolonged elimination t_1/2 in patients w/ severe renal impairment (serum creatinine >6 mg/100 mL). Contraindicated in patients w/ known existing prolongation of cardiac conduction intervals, particularly QTc, in patients w/ significant electrolyte disturbances (hypokalaemia, hyperkalaemia, hypomagnesaemia), or bradycardia, or in patients w/ underlying cardiac diseases eg, CHF due to increased risk of ventricular arrhythmia. Concomitant use w/ QT-prolonging drugs (including apomorphine); levodopa.

Dry mouth.

Contraindicated w/ QTc-prolonging medicinal products, anti-arrhythmics class IA (eg, disopyramide, hydroquinidine, quinidine), anti-arrhythmics class III (eg, amiodarone, dofetilide, dronedarone, ibutilide, sotalol), certain anti-psychotics (eg, haloperidol, pimozide, sertindole), certain anti-depressants (eg, citalopram, escitalopram), certain antibiotics (eg, erythromycin, levofloxacin, moxifloxacin, spiramycin), certain antifungals (eg, pentamidine), certain antimalarials (halofantrine, lumefantrine), certain GI medicines (eg, cisapride, dolasetron, prucalopride), certain antihistaminics (eg, mequitazine, mizolastine), certain medicines used in cancer (eg, toremifene, vandetanib, vincamine), certain other medicines (eg, bepridil, diphemanil, methadone), apomorphine; potent CYP3A4 inhibitors ie, PIs, systemic azole antifungals, some macrolides (erythromycin, clarithromycin, telithromycin). Not recommended w/ moderate CYP3A4 inhibitors ie, diltiazem, verapamil & some macrolides. Caution w/ bradycardia & hypokalaemia-inducing drugs; macrolides involved in QT-interval prolongation eg, azithromycin & roxithromycin. Increased plasma levels of levodopa.

GIT Regulators, Antiflatulents & Anti-Inflammatories / Antiemetics

A03FA03 - domperidone ; Belongs to the class of propulsives. Used in the treatment of functional gastrointestinal disorders.

Rx