Paracetamol: Adverse effects of paracetamol are rare and usually mild, although hematological reactions, including thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Skin rashes and other hypersensitivity reactions occur occasionally.
Vitamin B1: Adverse effect with thiamin is rare.
Vitamin B6: Long-term use of large doses of pyridoxine is associated with the development of severe peripheral neuropathies.