Divalgen 250/Divalgen 500 Dosage/Direction for Use

Valproic Acid is an extended-release product intended for once-a-day oral administration. Valproic Acid tablets should be swallowed whole and should not be crushed or chewed, or as prescribed by the physician.
Mania: Initial dose is 25 mg/kg/day, increasing as rapidly as possible to achieve therapeutic response or desired plasma level. The maximum recommended dosage is 60 mg/kg/day.
Complex Partial Seizures: Start at 10 to 15 mg/kg/day, increasing at 1 week intervals by 5 to 10 mg/kg/day to achieve optimal clinical response; if response is not satisfactory, check valproate plasma level; see full prescribing information for conversion to monotherapy. The maximum recommended dosage is 60 mg/kg/day.
Absence Seizures: Start at 15 mg/kg/day, increasing at 1 week intervals by 5 to 10 mg/kg/day until seizure control or limiting side effects. The maximum recommended dosage is 60 mg/kg/day.
Migraine: The recommended starting dose is 500 mg/day for 1 week, thereafter increasing to 1000 mg/day.