Dimezine Drug Interactions

No interaction studies have been performed.
The anticholinergic and sedative effects of Cinnarizine & Dimenhydrinate combination may be potentiated by monoamine oxidase inhibitors. Procarbazine may enhance the effect of Cinnarizine & Dimenhydrinate combination.
In common with other antihistamines, Cinnarizine & Dimenhydrinate combination may potentiate the sedative effects of CNS depressants including alcohol, barbiturates, narcotic analgesics and tranquillisers. Patients should be advised to avoid alcoholic drinks. Cinnarizine & Dimenhydrinate combination may also enhance the effects of antihypertensives, ephedrine and anticholinergics such as atropine and tricyclic antidepressants.
Cinnarizine & Dimenhydrinate combination may mask ototoxic symptoms associated with aminoglycosidic antibiotics and mask the response of the skin to allergic skin tests.
The concomitant administration of medicines that prolong the QT interval of the ECG (such as Class Ia and Class III anti-arrhythmics) should be avoided.
The information about potential pharmacokinetic interactions with cinnarizine and diphenhydramine and other medicinal products is limited. Diphenhydramine inhibits CYP2D6 mediated metabolism and caution is advised if Cinnarizine & Dimenhydrinate combination is combined with substrates of this enzyme, especially those with narrow therapeutic range.