Dimezine Adverse Reactions

The most frequently occurring ADRs are somnolence (including drowsiness, tiredness, fatigue, daze) occurring in about 8% of patients and dry mouth occurring in about 5% of patients in clinical trials. These reactions are usually mild and disappear within a few days even if treatment is continued. The frequency of ADRs associated with Cinnarizine & Dimenhydrinate combination in clinical trials and following spontaneous reports are as follows (Common ≥1/100 to <1/10, Uncommon ≥1/1,000 to <1/100, Rare ≥1/10,000 to <1/1,000 and Very Rare ≥1/10,000).
Blood and Lymphatic System Disorders: Very Rare: Leucopenia, Thrombopenia, Aplastic Anemia.
Immune System Disorders: Rare: Hypersensitivity Reactions (e.g., cutaneous reactions).
Nervous System Disorders: Common: Somnolence, Headache.
Uncommon: Paraesthesia, Amnesia, Tinnitus, Tremor, Nervousness, Convulsions.
Eye Disorders: Rare: Visual Disorders.
Gastrointestinal Disorders: Common: Dry Mouth, Abdominal Pain.
Uncommon: Dyspepsia, Nausea, Diarrhea.
Skin and Subcutaneous Tissue Disorders: Uncommon: Perspiration, Rash.
Rare: Photosensitivity.
Renal and Urinary Disorders: Rare: Urinary Hesitancy.
In addition the following adverse reactions are associated with dimenhydrinate and cinnarizine (frequency cannot be estimated from the available data): Dimenhydrinate: Paradoxical excitability (especially in children), worsening of an existing angle-closure glaucoma, reversible agranulocytosis.
Cinnarizine: Constipation, weight gain, tightness of the chest, cholestatic jaundice, extrapyramidal symptoms, lupus-like skin reactions, lichen planus.