Differin Dosage/Direction for Use

Adapalene (Differin) products should be applied to the face acne affected areas once a day at bedtime and after washing. Ensure that the affected areas are dry before application. A thin film of the product should be applied avoiding the eyes, lips and mucous membranes and the angles of the nose. (See PRECAUTIONS).
Clinical improvement for acne vulgaris is expected to be evident in four to eight weeks of treatment. Further improvement may be assessed after three months of treatment with Adapalene (Differin).
Clinical improvement for facial photoaging, periorbital wrinkles, ephelides/melanosis and forehead wrinkles is expected in 12 weeks. Further improvement may be assessed after 24 weeks of treatment with Adapalene (Differin) 0.3%.
Cutaneous safety of Adapalene (Differin) products has been demonstrated over a 12- months period.
If patients use cosmetics, these should be non-comedogenic and non-astringent.
The safety and effectiveness of Adapalene (Differin) products have not been studied in children below 12 years of age.
The safety and effectiveness of Adapalene (Differin) 0.3% has not been established in patients under the age of 35 years of age with facial photoaging.
Safety and effectiveness in geriatric patients age 65 and above have not been established.
Cream: Differin Cream should be applied to the acne affected areas once a day before retiring and after washing. A thin film of the product should be applied avoiding the eyes and lips (see Special Warnings and Special Precautions for Use). Ensure that the affected areas are dry before application.
With patients for whom it is necessary to reduce the frequency of application or to temporarily discontinue treatment, frequency of application may be restored or therapy resumed once it is judged that the patient can again tolerate the treatment.
If patients use cosmetics, these should be non-comedogenic and non-astringent.
The safety and effectiveness of Differin Cream has not been studied in neonates and young children.