Differin Description

Adapalene (Differin) 0.1% (1mg/g) Gel: One gram contains: Adapalene Ph. Eur. 1 mg.
Adapalene (Differin) 0.3% (3mg/g) Topical Gel: One gram contains: Adapalene Ph. Eur. 3 mg.
Adapalene (Differin) 0.1% (1mg/g) Cream: One gram contains: Adapalene Ph. Eur. 1 mg.
Differin Cream contains 0.1% w/w adapalene (BAN, INN, USAN), as the active ingredient in a cream base containing carbomer, PEG-20 methylglucose sesquistearate, glycerol, natural squalane, methyl parahydroxybenzoate, propyl parahydroxybenzoate, disodium edetate, methylglucose sesquistearate, phenoxyethanol, cyclomethicone, sodium hydroxide to adjust the pH to 6.5 ± 0.2 and purified water to complete the formulation.
Excipients with known effect: Topical gel 0.1%: Methyl parahydroxybenzoate (E218), propylene glycol: One gram of gel contains 40mg of Propylene glycol (E1520).
Topical gel 0.3% and Cream: Methyl parahydroxybenzoate (E218) and propyl parahydroxybenzoate (E216).
Excipients/Inactive Ingredients: Topical gel 0.1%: Carbomer 940, Propylene Glycol, Poloxamer 182, Disodium edetate, Methyl para-hydroxybenzoate, Phenoxyethanol, Sodium hydroxide solution (qs pH = 5.0) and Purified water.
Topical gel 0.3% and Cream: Carbomer 934P, PEG-20 methyl glucose sesquistearate, Glycerol, Natural squalane, Methyl parahydroxybenzoate, Propyl parahydroxybenzoate, Disodium edetate, Methyl glucose sesquistearate, Phenoxyethanol, Cyclomethicone, Sodium hydroxide solution (qs pH = 6.3 to 6.7) and Purified water.