Diabemin XR Drug Interactions

Inadvisable combinations: Alcohol: Increased risk of lactic acidosis in acute alcohol intoxication, particularly in case of fasting or malnutrition and hepatic insufficiency. Avoid consumption of alcohol and alcohol-containing medications.
Associations requiring precautions for use: Glucocorticoids (systemic and local routes) and tetracosactides, beta-2-agonists (e.g. salbutamol, terbutaline), danazol, chlorpromazine at high dosages of 100 mg per day and diuretics have intrinsic hyperglycemic activity. Inform the patient and perform more frequent blood glucose monitoring, especially at the beginning of treatment. If necessary, adjust the dosage of the antidiabetic drug during therapy with the other drug and upon its discontinuation.
Diuretics especially loop diuretics, may increase the risk of lactic acidosis due to their potential to decrease renal function.
ACE-inhibitors may decrease the blood glucose levels. If necessary, adjust the dosage of the antidiabetic drug during therapy with the other drug and upon its discontinuation.
While taking metformin, patients must not use iodinated contrast agents.
The doctor or pharmacist should be informed about concurrent or recently taken medications such as nonsteroidal anti-inflammatories or even an over-the-counter medication.
There is a possible interaction between anticoagulants and metformin hydrochloride. Patients receiving these two medicines concomitantly need an adjustment of the anticoagulant dosage.
Cimetidine decreases the renal clearance of metformin, therefore a dose reduction should be considered.