Dexketoprofen 50 mg/2 mL solution for injection or concentrate for solution for infusion must not be administered in the following cases: patients with hypersensitivity to the active substance, to any other NSAID, or to any of the excipients; patients in whom substances with a similar action (e.g. acetylsalicylic acid and other NSAIDs) precipitate attacks of asthma, bronchospasm, acute rhinitis, or cause nasal polyps, urticaria or angioneurotic oedema; patients with history of gastrointestinal bleeding or perforation, related to previous NSAIDs therapy; patients with active or suspected peptic ulcer/gastrointestinal haemorrhage or any history of recurrent peptic ulcer/haemorrhage (two or more distinct episodes of proven ulceration or bleeding) or chronic dyspepsia; patients who have other active bleedings or bleeding disorders; patients with Crohn's disease or ulcerative colitis; patients with severe heart failure; patients with a history of bronchial asthma; patients with moderate to severe renal dysfunction (creatinine clearance <50 mL/min); patients with severely impaired hepatic function (Child-Pugh score 10 - 15); patients with haemorrhagic diathesis and other coagulation disorders; patients with severe dehydration (caused by vomiting, diarrhoea or insufficient fluid intake); during the third trimester of pregnancy and lactation period; neuraxial (intrathecal or epidural) administration due to its ethanol content.
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