Incompatibilities: Dexketoprofen 50 mg/2 mL must not be mixed in a small volume (e.g. in a syringe) with solutions of dopamine, promethazine, pentazocine, pethidine or hydroxyzine, as this will result in a precipitation of the solution.
The diluted solutions for infusion obtained as stated in the special precaution for disposal & other handling must not be mixed with promethazine or pentazocine. This medicinal product must not be mixed with other medicinal products except those mentioned in the special precaution for disposal & other handling.
Special Precautions for Disposal and other Handling: Dexketoprofen 50 mg/2 mL solution for injection or concentrate for Solution for Infusion has shown to be compatible when mixed in small volumes (e.g. in a syringe) with injectable solutions of heparin, lidocaine, morphine and theophylline.
For administration as intravenous infusion the content of one ampoule (2 mL) of Dexketoprofen 50 mg/2 mL solution for injection or concentrate for Solution for Infusion should be diluted in a volume of 30 to 100 mL of normal saline, glucose or Ringer lactate solution. The solution should be diluted aseptically and protected from natural daylight. The diluted solution is a clear solution.
Dexketoprofen 50 mg/2 mL solution for injection or concentrate for Solution for Infusion, diluted in a volume of 100 ml of normal saline or glucose solution has shown to be compatible with the following medicinal products: dopamine, heparin, hydroxyzine, lidocaine, morphine, pethidine and theophylline. No sorption of the active ingredient has been found when diluted solutions of Dexketoprofen Solution for injection or concentrate for Solution for Infusion have been stored in plastic bags or administration devices made of Ethyl Vinyl Acetate (EVA), Cellulose Propionate (CP), Low Density PolyEthylene (LDPE) and PolyVinyl Chloride (PVC).
Dexketoprofen 50 mg/2 mL solution for injection or concentrate for Solution for Infusion is for single use only and any unused solution should be discarded. Prior to administration, the solution should be inspected visually to make sure it is clear and colourless: it should not be used if particulate matter is observed.
Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
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