If any of the adverse effects get serious, or if the patient notices any adverse effects not listed, please tell the doctor or pharmacist.
Serious reactions associated with the use of Cybelle, as well as the related symptoms are described in Precautions.
The following adverse effects have been reported by users of Cybelle, although they need not to be caused by Cybelle. These adverse effects may occur in the first few months that the patient is using Cybelle and usually lessen with time.
If the patient suffers from hereditary angioedema, exogenous estrogen can trigger or exacerbate symptoms of angioedema. (See table.)

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