Smoking; diabetes; overwt; high BP; valve or heart rhythm disorder; superficial phlebitis; varicose veins; family history of thrombosis, heart attack or stroke, breast cancer & high levels of cholesterol or triglycerides; migraine; epilepsy; liver or gallbladder disease; Crohn's disease, ulcerative colitis; polycystic ovary syndrome; SLE; hemolytic uremic syndrome; sickle cell disease; hearing loss, porphyria, herpes gestationis, Sydenham's chorea; chloasma; hereditary angioedema.