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Celecoxib should not be used after coronary artery bypass surgery as there may be an increased risk of adverse effects such as myocardial infarction and stroke. It should be used with caution, if at all, in patients with a history of ischemic heart disease, peripheral arterial disease, or cerebrovascular disease; it should also be used with caution in patients with significant risk factors for cardiovascular disease such as hypertension, hyperlipidemia, and diabetes mellitus. Celecoxib is not given to patients with allergy to NSAIDs and those with asthma. Use the lowest effective dose for the shortest duration of treatment. Intake of celecoxib should be stopped with appearance of skin rash and signs of hypersensitivity.
Use in the Elderly (> 65 years of age): In the elderly, frail and debilitated, the dosage should be reduced to the lowest level providing control of symptoms and adjusted when necessary.
