RA including juvenile idiopathic arthritis, OA, & ankylosing spondylitis, & in the adjunctive treatment of adenomatous colorectal polyps. Management of acute pain & dysmenorrhea.
AdultOA 200 mg daily given as single dose or in 2 divided doses. If necessary, 200 mg bid may be used. RA 100-200 mg bid. Ankylosing spondylitis Initially 200 mg daily as single dose or in 2 divided doses. Pain & dysmenorrhea Initially 400 mg followed by an additional dose of 200 mg, if necessary, is recommended on the 1st day; thereafter dose is 200 mg bid. Adjunctive treatment of adenomatous colorectal polyps 400 mg bid.
May be taken with or without food: Dose for adenomatous colorectal polyps may be given w/ food.
Contraindications
Hypersensitivity to celecoxib & sulfonamides. Discontinue use if signs or symptoms of organ toxicity develop. Not to be given to patients who have history of CVA, MI, CABG, uncontrolled HTN & CHF NYHA II-IV. Patients w/ inflammatory bowel disease; dehydrated patients. Renal impairment (CrCl <30 mL/min). Not to be used in severe hepatic impairment (Child-Pugh category C).
Discontinue use in appearance of skin rash & signs of hypersensitivity. Not to be given to patients w/ allergy to NSAIDs & those w/ asthma. Not to be used after CABG. Patients w/ history of ischemic heart disease, peripheral arterial disease, or cerebrovascular disease; significant risk factors for CV disease eg, HTN, hyperlipidemia, & DM. Pregnancy & lactation.
Changes in plasma conc w/ drugs that inhibit or induce CYP450 isoenzyme CYP2C9. Increased plasma conc w/ fluconazole. May affect drugs metabolized by isoenzyme CYP2C9.
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