Coumadin Adverse Reactions

Potential adverse reactions to Coumadin may include:
Hemorrhage from any tissue or organ. This is a consequence of the anticoagulant effect. The signs and symptoms will vary according to the location and degree or extent of the bleeding. Hemorrhagic complications may present as paralysis; headache, chest, abdomen, joint or other pain; shortness of breath, difficult breathing or swallowing; unexplained swelling; or unexplained shock. Therefore, the possibility of hemorrhage should be considered in evaluating the condition of any anticoagulated patient with complaints which do not indicate an obvious diagnosis. Bleeding during anticoagulant therapy does not always correlate with prothrombin activity (see Treatment under Overdosage).
Bleeding which occurs when the PT is within the therapeutic range warrants diagnostic investigation since it may unmask a previously unsuspected lesion eg, tumor, ulcer, etc.
Necrosis of skin and other tissues (see Warnings).
Other adverse reactions are infrequent and consist of alopecia, urticaria, dermatitis, fever, nausea, diarrhea, abdominal cramping, systemic cholesterol microembolization, purple toes syndrome, cholestatic hepatic injury and hypersensitivity reactions.
Priapism has been associated with anticoagulant administration; however, a causal relationship has not been established.