Combimist Adverse Reactions

The most frequent side effects reported in clinical trials were headache, throat irritation, cough, dry mouth, gastrointestinal motility disorders (including constipation, diarrhoea and vomiting), nausea and dizziness.
Adverse Reactions: Immune system disorders: Rare: Anaphylactic reaction, hypersensitivity, angioedema of the tongue, lips and face.
Metabolism and nutrition disorders: Rare: Hypokalaemia.
Not known: Lactic acidosis.
Psychiatric disorders: Uncommon: Nervousness.
Rare: Mental disorder.
Nervous system disorders: Uncommon: Dizziness, headache, tremor.
Eye Disorders: Rare: Accommodation disorder, corneal oedema.
Rare: Eye pain, increased intraocular pressure, mydriasis, blurred vision, conjunctival hyperaemia, halo vision.
Cardiac Disorders: Uncommon: Palpitations, tachycardia.
Rare: Arrhythmia, atrial fibrillation, myocardial ischaemia, supraventricular tachycardia.
Respiratory, thoracic and mediastinal disorders: Uncommon: Cough, dysphonia, throat irritation.
Rare: Bronchospasm, paradoxical bronchospasm, dry throat, laryngospasm, pharyngeal oedema.
Gastrointestinal disorders: Uncommon: Dry mouth, nausea.
Rare: Gastrointestinal motility disorder (e.g. diarrhoea), constipation, vomiting, mouth oedema, stomatitis.
Skin and subcutaneous tissue disorders: Uncommon: Skin reactions.
Rare: Rash, urticaria, pruritus.
Musculoskeletal and connective tissue disorders: Rare: Muscle spasm, muscular weakness, myalgia.
Renal and urinary disorders: Rare: Urinary retention.
General disorders and administration site conditions: Rare: Asthenia.
Investigations: Uncommon: Systolic blood pressure increased.
Rare: Diastolic blood pressure decreased.