IV/IMAdultSerious infections 600-1,200 mg daily in 2, 3 or 4 equal doses. More severe infections 1,200-2,700 mg daily in 2, 3 or 4 equal doses. Max: 4,800 mg IV daily. Childn <1 mthSerious infections 15-25 mg/kg daily in 3-4 equal doses. More infections 25-40 mg/kg daily in 3-4 equal doses.
Risk of fatal Gasping syndrome in premature infants due to benzyl alcohol content. History of GI disease especially colitis. Perform periodic liver & kidney function test during prolonged therapy. Super-infection may occur in prolonged use. Atopic individuals. Pregnancy & lactation. Neonates, infant <1 mth.
Enhanced action of other neuromuscular blockers. Antagonism w/ erythromycin (in vitro). Increased coagulation test (PT/INR) &/or bleeding w/ vit K antagonist (eg, warfarin, acenocoumarol & fluindione).
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