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Pharmacology: Pharmacokinetics: Oxacillin sodium, with normal doses, has insignificant concentrations in the cerebrospinal and ascetic fluids. It is found in therapeutic concentrations in the pleural, bile, and amniotic fluids. Oxacillin sodium is rapidly excreted as unchanged drug in the urine by glomerular filtration and active tubular secretion.
Oxacillin sodium binds to serum protein, mainly albumin. The degree of protein binding reported varies with the method of study and the investigator, but generally has found to be 94.2 ±2.1%.
Intramuscular injections give peak serum levels 30 minutes after injection. A 250 mg dose gives a level of 5.3 μg/mL while a 500 mg dose peaks at 10.9 μg/mL. Intravenous injection gives a peak about 5 minutes after injection is completed. Slow IV dosing with 500 mg gives a 5 minute peak of 43 μg/mL with a half-life of 20 to 30 minutes.
