Cholivex Mechanism of Action

Psychostimulant and Nootropic.
Pharmacology: Pharmacodynamics: Citicoline, being the precursor of key ultrastructural components of a cellular membrane (mainly phospholipids), possesses wide range of activities, promotes restoration of the damaged cell membranes, inhibits action of phospholipases, what prevents excessive formation of free radicals and destruction of cells, affects the mechanisms of apoptosis.
In the acute period of stroke it reduces the volume of damaged tissue, improves cholinergic transmission. In head injury it reduces duration of a post-traumatic coma and intensity of neurologic symptoms.
Citicoline improves observed during hypoxia symptoms, such as memory impairment, emotional liability, lack of initiative, difficulties at conducting of daily actions and self-service.
The drug product does not influence breath, pulse and arterial pressure; therefore long treatment is possible.
Pharmacokinetics: Absorption: Citicoline is well absorbed following intravenous and intramuscular injection.
Distribution: Citicoline administered is widely distributed in brain structures, with a rapid incorporation of the choline fraction into structural phospholipids, and of the cytosine reaction into cytidine nucleotides and nucleic acids.
Metabolism: It is metabolised to choline and cytidine. Following parenteral administration, choline plasma concentration increases significantly.
Elimination: Only 15% of citicoline is eliminated from human body. Less than 3% is via kidneys; approximately 12% is eliminated with CO₂.