Centrapraz Dosage/Direction for Use

Pantoprazole may be administered intravenously through a dedicated line or through a Y-site.
The intravenous line should be flushed before and after administration of Pantoprazole for injection with either water for injection 5% Dextrose Injection USP, 0.9% Sodium Chloride Injection. Or as prescribed by the physician.
Pathological Hypersecretion Associated with Zollinger-Ellison Syndrome: The dosage of Pantoprazole for Injection in patients with pathological hypersecretory conditions associated with Zollinger-Ellison syndrome or other neoplastic conditions varies with individual patients. The recommended adult dosage is 80 mg every 12 hours. The frequency of dosing can be adjusted to individual patient needs based on acid output measurements.
In those patients who need a higher dosage, 80 mg every 8 hours is expected to maintain acid output below 10 mEq/h. Daily doses higher than 240 mg or administered for more than 6 days have not been studied. Transition from oral to I.V. and from I.V. to oral formulations of gastric acid inhibitors should be performed in such a manner to ensure continuity of effect of suppression of acid secretion. Patients with Zollinger-Ellison syndrome may be vulnerable to serious clinical complications of increased acid production even after a short period of loss of effective inhibition.