Centrapraz Caution For Usage

Direction for Reconstitution: Dissolve the content of the vial in diluent. If any particle is visible after dissolving the contents, do not use the solution.
Pantoprazole is compatible with the following solutions: Water for Injection 5% Dextrose Injection USP, 0.9% Sodium Chloride Injection USP, or Lactated Ringer's Injection USP.
Midazolam HCl has been shown to be incompatible with Y-site administration of Pantoprazole may not be compatible with products containing zinc. When Pantoprazole is administered through a Y-site, and immediately stop use if precipitation or discoloration occurs.
Treatment with Pantoprazole Injection should be discontinued as soon as the patient is able to be treated with Pantoprazole delayed release tablets.
Parenteral route of administration other than intravenous is not recommended. No dosage adjustment is necessary in patients with renal impairment, hepatic impairment, or for elderly patients. Doses higher than 40 mg/day have not been studied in hepatically-impaired patients. No dosage adjustment is necessary in patients undergoing hemodialysis.
Fifteen Minute Infusion: Pantoprazole for Injection should be reconstituted with 10 mL of diluent and further diluted (admixed) with 100 mL of 5% Dextrose Injection USP, 0.9% Sodium Chloride Injection USP, or Lactated Ringer's Injection USP, to a final concentration of approximately 0.4 mg/mL. The reconstituted solution may be stored for up to 4 hours at room temperature prior to further dilution. The admixed solution may be stored at room temperature and must be used within 24 hours from the time of initial reconstitution. Both the reconstituted solution and the admixed solution do not need to be protected from light. Pantoprazole for admixtures should be administered intravenously over a period of approximately 15 minutes at a rate of approximately 7 mL/min.