Celevo Warnings

No significant effect of Levofloxacin on the peak plasma concentrations, AUC, and other disposition parameters for R- and S-warfarin was detected in a clinical study involving healthy volunteers.
Antidiabetic Agents: Disturbances of blood glucose, including hyperglycemia and hypoglycaemia, have been reported in patients treated concomitantly with quinolone and an antidiabetic agent. Therefore, careful monitoring of blood glucose is recommended when these agents are co­-administered.
Non-Steroidal Anti-Inflammatory Drugs: The concomitant administration of a non­-steroidal anti-inflammatory drug with a quinolone, including Levofloxacin, may increase the risk of CNS stimulation and convulsive seizures.
Theophylline: No significant effect of Levofloxacin on the plasma concentrations, AUC, and other disposition parameters for theophylline was detected in a clinical study involving healthy volunteers.
Cyclosporine: No significant effect of Levofloxacin on the peak plasma concentrations, AUC, and other disposition parameters for cyclosporine was detected in a clinical study involving healthy volunteers.
Digoxin: No significant effect of Levofloxacin on the peak plasma concentrations, AUC, and other disposition parameters for digoxin was detected in a clinical study involving healthy volunteers. Levofloxacin absorption and disposition kinetics were similar in the presence of absence of digoxin.
Probenecid and Cimetidine: No significant effect of probenecid or cimetidine on the C_max of levofloxacin was observed in a clinical study involving healthy volunteers.