Levofloxacin is given as the hemihydrate but doses are expressed in terms of the base; levofloxacin hemihydrate 256 mg is equivalent to about 250 mg of the base. Usual doses range from 250 mg once daily for 3 days for uncomplicated urinary-tract infections to 250 or 500 mg once or twice daily for 10 to 14 days for most other susceptible infections. A 28-day course of treatment with a dose of 500 mg daily should be given for chronic bacterial prostatitis. An alternative regimen of 750 mg once daily for 7 to 14 days may be used for complicated skin infections and for hospital-acquired pneumonia; a shorter course of 750 mg once daily for 5 days may be given for community-acquired pneumonia or for acute bacterial sinusitis. Dosing should be reduced in patients with renal impairment.
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