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For osteoarthritis and rheumatoid arthritis, the lowest dose of celecoxib should be sought for each patient. These doses can be given without regard to timing of meals.
Osteoarthritis (OA): Recommended Oral Dose: 200 mg/day administered as a single dose or as 100 mg twice daily. If necessary a dose of 200 mg twice daily may be used.
Rheumatoid Arthritis (RA): Recommended Oral Dose: 100-200 mg twice daily.
Juvenile Rheumatoid Arthritis: Patients >25 kg: 100 mg twice daily; ≥10 to ≤25 kg: 50 mg twice daily.
Ankylosing Spondylitis: 200 mg once daily or in 2 divided doses.
Management of Acute Pain and Treatment of Primary Dysmenorrhea: 400 mg initially, followed by an additional 200-mg dose if needed on the 1st day. On the subsequent days, the recommended dose is 200 mg twice daily as needed.
Familial Adenomatous Polyposis (FAP): Usual medical care for FAP patients should be continued while on celecoxib. To reduce the number of adenomatous colorectal polyps in patients with FAP, the recommended oral dose is 400 mg twice daily to be taken with food.
Special Populations: Hepatic Insufficient Patients: The daily recommended dose of celecoxib caps in patients with moderate hepatic impairment (Child-Pugh Class B) should be reduced by approximately 50%.
