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Patients with known hypersensitivity to celecoxib and those who have demonstrated allergic-type reactions to sulfonamide.
Patients who have experienced asthma, urticaria, or allergic-type reactions after taking acetyl salicylic acid (ASA) or other NSAIDs including other COX-2 specific inhibitors. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients.
Patients with renal impairment associated with CrCl of <30 mL/min.
Patients with severe hepatic impairment (Child-Pugh Class C), heart failure and inflammatory bowel disease.
Patients who have previously had a myocardial infarction (MI) or stroke and in the peri-operative period undergoing cardiac or major vascular surgery.
