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Adults: 750 mg twice daily.
For infections the usual dose is 750 mg every 8 hours. In case of severe infections 1.5 g of cefuroxime is given intravenously for about 6 or 8 hours.
Or as directed by the Physicians.
The reconstituted solution should be used immediate after preparation. Do not allow to freeze.
1.5 mg: After constitution, this drug may be given intravenously or by deep intramuscular injection into a large muscle mass. Before injecting intramuscularly, aspiration is necessary to avoid inadvertent injection into a blood vessel.
For Intramuscular Use: Cefuroxime should be constituted with 6 mL of sterile water for injection. Shake gently to disperse and withdraw completely the resulting suspension for injection.
For Intravenous Use: Cefuroxime should be constituted with not less than 12 mL of sterile water for injection. Shake gently and then slowly inject the solution into a vein or give it through the tubing system.
The usual adult dosage range for this drug is 750 mg to 1.5 grams every 8 hours, usually for 5 to 10 days.
In life-threatening infections or infections due to less susceptible organisms, 1.5 grams every 6 hours may be required. In bacterial meningitis, the dosage should not exceed 3 grams every 8 hours. The recommended dosage for uncomplicated gonococcal infection is 1.5 grams given intramuscularly as a single dose at 2 different sites together with 1 gram of oral probenecid.
For preventive use for clean-contaminated or potentially contaminated surgical procedures, 1.5-gram dose administered intravenously just before surgery (approximately one-half to 1.5 hours before the initial incision) is recommended. Thereafter, give 750 mg intravenously or intramuscularly every 8 hours when the procedure is prolonged. For preventive use during open chest surgery, a 1.5-gram dose administered intravenously at the induction of anesthesia and every 12 hours thereafter for a total of 6 grams is recommended.
For pediatric patients above 3 months of age, administration of 50 to 100 mg/kg/day in equally divided doses every 6 to 8 hours has been successful for most infections susceptible to cefuroxime. The higher dosage of 100 mg/kg/day (not to exceed the maximum adult dosage) should be used for the more severe or serious infections. In bone and joint infections, 150 mg/kg/day (not to exceed the maximum adult dosage) is recommended in equally divided doses every 8 hours. In cases of bacterial meningitis, a larger dosage is recommended, 200 to 240 mg/kg/day in equally divided doses every 6 to 8 hours. The total daily dose for pediatric patients should not exceed 6 grams.
Impaired Renal Function: A reduced dosage must be employed when renal function is impaired. Dosage should be determined by the degree of renal impairment. (See table.)
Click on icon to see table/diagram/imageIn pediatric patients with renal insufficiency, the frequency of dosing should be modified consistent with the recommendations for adults.
