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Pharmacotherapeutic Group: Calcium Supplement.
Pharmacology: Calcidin: Pharmacodynamics: Mechanism of Action: Calcium carbonate is a calcium supplement that is used in deficiency states and as an adjunct in the prevention and treatment of osteoporosis. Vitamin D3 is a fat-soluble sterol, it aids in the regulation of calcium and phosphate homeostasis and bone mineralisation.
Pharmacokinetics: Absorption: Calcium carbonate: About 15-25% gets absorbed in the GI tract.
Converted to calcium chloride by gastric acid.
Vitamin D: Well-absorbed in the GI tract in the presence of bile.
Metabolism: Vitamin D: Undergoes hydroxylation in the liver and kidney to form the active metabolite, 1,25-dihydrocolecalciferol.
Excretion: Vitamin D and metabolites are mainly excreted in the bile and feces.
