Given by deep IM inj, slow IV inj over 3-5 min, or intermittent or continuous IV infusion.
Adult 1 or 2 g every 8 hr.
Severe infection Up to 12 g daily.
Childn 20-40 mg/kg every 6-8 hr in childn & older infant, 20-40 mg/kg every 8 hr in neonate 1-4 wk old, & 20-40 mg/kg every 12 hr in neonate up to 1 wk old.
Severe infection Up to 200 mg/kg daily. Max: 12 g daily.
Specific treatment: Uncomplicated UTI 1 g IM bid.
Uncomplicated gonorrhea 2 g IM as single dose w/ oral probenecid 1 g.
Surgical infection prophylaxis Adult 2 g IM or IV 30-60 min before procedure, then every 6 hr for up to 24 hr.
Infant/childn 30-40 mg/kg at same interval as adult.
Neonate 30-40 mg/kg every 8-12 hr.
Cesarean section 2 g IV as single dose after umbilical cord clamping, or optional 3-dose regimen w/ further 2 g doses 4 & 8 hr later.
Renal impairment In adults, after an initial loading dose of 1-2 g, maintenance doses are:
CrCl 30-50 mL/min 1-2 g every 8-12 hr,
10-29 mL/min 1-2 g every 12-24 hr,
5-9 mL/min 0.5-1 g every 12-24 hr,
<5 mL/min 0.5-1 g every 24-48 hr,
hemodialysis patient Repeat loading dose after each session.
Sign Out
