Sign Out
The hypotensive effects of Methyldopa are potentiated by diuretics, other antihypertensives, and drugs with hypotensive effects. However, there have been reports of paradoxical antagonism of the hypotensive effects by tricyclic antidepressants, antipsychotics, and beta blockers.
Sympathomimetics may also antagonize the hypotensive effects.
There may be an interaction between Methyldopa and MAOIs and care is required if they are given concomitantly. Caution is also needed with entacapone since it might inhibit the metabolism of Methyldopa.
Patients receiving Methyldopa may require lower doses of general anaesthetics.
