The following adverse effects have also been reported for cephalosporin-class antibiotics: Hypersensitivity reactions including eosinophilia, joint pain or inflammation, edema, facial edema, genital and anal pruritus, angioedema, shock, hypotension, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, and exfoliative dermatitis; anaphylaxis including a few fatalities; thrombocythemia, leukocytosis, granulocytosis, monocytosis, lymphocytopenia, basophilia, anemia, aplastic anemia, pancytopenia, hemolytic anemia, epistaxis or hemorrhage; renal dysfunction, toxic nephropathy; vaginal candidiasis, menstrual irregularities; transient increase in γ-glutamyl transferase concentration; increased serum bilirubin and/or lactate dehydrogenase; decreased serum albumin and/or total protein; hepatic dysfunction including cholestasis; thrombophlebitis; malaise, fatigue, nightmares, vertigo, hyperactivity, nervousness or anxiety, agitation, hallucinations, insomnia, somnolence, weakness, hot flushes, alteration in color perception, confusion, hypertonia; chest pain, pleural effusion, pulmonary infiltrate, respiratory distress, cough, rhinitis; increased or decreased serum glucose concentration.