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General: Since the vasodilatation induced by amlodipine is gradual in onset, acute hypertension has rarely been reported after oral administration. Nonetheless, caution should be exercised when administrating amlodipine with any other peripheral vasodilator particularly in patients with severe aortic stenosis.
Use in patients with Congestive Heart Failure: In general, amlodipine should be used with caution in patients with heart failure.
Beta-Blocker Withdrawal: Amlodipine is not a beta blocker and hence gives no protection against the dangers of abrupt beta blocker withdrawal; any such withdrawal should be by gradual reduction of the dose of beta blocker.
Patients with Hepatic Failure: Since amlodipine is extensively metabolised by the liver and the plasma elimination half-life is 56 hours in patients with impaired hepatic function, caution should be exercised when administrating amlodipine to such patients.
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