It is given by mouth as the besilate, alone or in combination with other agents, in the management of hypertension, in doses equivalent to 5 mg amlodipine daily, as a single dose. The dose may be increased, if necessary, to the equivalent of 10 mg daily. Similar doses are given in the treatment of stable angina and Prinzmetal's angina. Small, fragile, or elderly individuals, or patients with hepatic insufficiency may be started on 2.5 mg once daily and this dose may be used in combination with other antihypertensives.